Presentation by James Donald McCully, PhD

Mitochondria play a prominent role in cellular homeostasis and function and are dependent upon oxygen uptake. Ischemia adversely modulates mitochondrial structure and function resulting in loss of cellular viability and organ dysfunction.

In this presentation we will describe a novel therapeutic modality, mitochondrial transplantation, that allows for the rescue of organ viability and function resulting from ischemia-reperfusion injury and discuss current and potential clinical applications.